Avviso di ricerca e selezione per la figura di Assistenti di Ricerca
La Fondazione Italiana Sclerosi Multipla, per conto del Progetto RISM, ha deciso di potenziare la rete degli Assistenti di Ricerca dedicati al Progetto promuovendo una ricerca di personale per la selezione di nuove figure di ambo i sessi, che opereranno nelle seguenti regioni: Calabria, Campania, Friuli Venezia Giulia, Lazio, Lombardia, Marche, Piemonte, Sicilia, Sardegna e Veneto.
Gli Assistenti di Ricerca selezionati prenderanno parte al RISM e svolgeranno la loro attività di ricerca supportando l'implementazione dello stesso presso i Centri Clinici che hanno aderito all’iniziativa nelle varie regioni.
I candidati interessati potranno inviare la propria candidatura via email a: registroitalianosm@aism.it allegando copia del proprio curriculum vitae e dettagliata e specifica esplicitazione delle esperienze pregresse.
Caratterizzare il rischio di eventi avversi gravi durante il sequencing dei trattamenti nei pazienti con Sclerosi Multipla: analisi di coorte basata sul Registro Italiano Sclerosi Multipla.
SINOSSI E RISULTATI
During the last years, there has been a paradigm shift in the treatment of multiple sclerosis (MS) thanks to the availability of a broad spectrum of immune therapies, with distinct mechanisms of action, risk- profiles and side-effects. However, the identification of an ‘optimal choice’ for individual patients must consider not only treatment efficacy and adherence but also, the Adverse Events profile. This choice has become increasingly complex, especially with regard to the common clinical scenario of various sequential treatment possibilities that may be associated with additive, though different, effects on immune system. This study aims to provide an overview of the risk related to different treatment sequencies, trying to provide, for each treatment decision, individual risk stratification and consequent pharmacovigilance that needs to be maintained. The study will be conducted by extracting and analyzing the data present in the Italian Multiple Sclerosis Register collected from its establishment to 1st May 2020; we will then assess the incidence of adverse events, particularly infections, lymphopenia (grade III-IV) and malignancies, estimate the time to adverse event and the comparative safety of the different therapeutic approaches.
Fondazione Italiana Sclerosi Multipla – FISM – Ente del Terzo Settore/ETS e, in forma abbreviata, FISM ETS. Iscrizione al RUNTS Rep. N° 89695 - Fondazione con Riconoscimento di Personalità Giuridica - C.F. 95051730109
Caratterizzare il rischio di eventi avversi gravi durante il sequencing dei trattamenti nei pazienti con Sclerosi Multipla: analisi di coorte basata sul Registro Italiano Sclerosi Multipla.
During the last years, there has been a paradigm shift in the treatment of multiple sclerosis (MS) thanks to the availability of a broad spectrum of immune therapies, with distinct mechanisms of action, risk- profiles and side-effects. However, the identification of an ‘optimal choice’ for individual patients must consider not only treatment efficacy and adherence but also, the Adverse Events profile. This choice has become increasingly complex, especially with regard to the common clinical scenario of various sequential treatment possibilities that may be associated with additive, though different, effects on immune system. This study aims to provide an overview of the risk related to different treatment sequencies, trying to provide, for each treatment decision, individual risk stratification and consequent pharmacovigilance that needs to be maintained. The study will be conducted by extracting and analyzing the data present in the Italian Multiple Sclerosis Register collected from its establishment to 1st May 2020; we will then assess the incidence of adverse events, particularly infections, lymphopenia (grade III-IV) and malignancies, estimate the time to adverse event and the comparative safety of the different therapeutic approaches.
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